Marjan S. Rupnik, Ph.D.

Professor and Head,
Institute of Physiology
Medical faculty University of Maribor

- BSc Biology/Physiology, University of Ljubljana, Slovenia, 1991
- MSc
, Physiology, Medical faculty, University of Ljubljana, 1993
- PhD, Cell Physiology, Medical faculty, University of Ljubljana, 1996
- Assistant Professor
of Pathophysiology, Medical faculty, University of Ljubljana, 1997
- Group leader, Department of Neuroendocrinology, European Neuroscience Institute/Max- Planck-Institute for Biophysical Chemistry, Goettingen, Germany, 2000-2005
- Associate Professor of Physiology, Faculty of Medicine  University of Maribor, 2004
- Full Professor of Physiology, Faculty of Medicine, University of Maribor, 2009
- IUPS Council member, since 2007
- CO CIPKeBiP, since 2009




Last modified:
 
February 2011

phone: +386 2 330 5854   recent radio interview

fax: +386 2 330 5853

email: marjan.rupnik @uni-mb.si

Interview Zdravstveni vestnik

     


RECENT PUBLICATIONS:

 Nyqvist D, Speier S, Rodriguez-Diaz R, Molano RD, Lipovsek S, Rupnik M, Dicker A, Ilegems E, Zahr-Akrawi E, Molina J, Lopez-Cabeza M, Villate S, Abdulreda M, Ricordi C, Caicedo A, Pileggi A, Berggren PO. Donor Islet Endothelial Cells in Pancreatic Islet Revascularization. Diabetes. 2011 Aug 26.

 Dolenšek J, Skelin M, Rupnik SM. (2011) Calcium dependencies of regulated exocytosis in different endocrine cells. Physiol Res. Jul 19.

 Mandic SA, Skelin M, Johansson JU, Rupnik MS, Berggren PO, Bark C. (2011) Munc18-1 and Munc18-2 Proteins Modulate {beta}-Cell Ca2+ Sensitivity and Kinetics of Insulin Exocytosis Differently. J Biol Chem. 286(32):28026-40.

 Bonner C, Farrelly AM, Concannon CG, Dussmann H, Baquié M, Virard I, Wobser H, Kögel D, Wollheim CB, Rupnik M, Byrne MM, König HG, Prehn JH. Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation. (2011) J Biol Chem. 286(29):25719-28.

 Balabanič D, Rupnik M, Klemenčič AK. (2011) Negative impact of endocrine-disrupting compounds on human reproductive health. Reprod Fertil Dev. 23(3):403-16.

 Skelin M, Rupnik M. (2011) cAMP increases the sensitivity of exocytosis to Ca(2+) primarily through protein kinase A in mouse pancreatic beta cells. Cell Calcium. 49(2):89-99.

 Huang YC, Rupnik M, Gaisano HY. (2011) Unperturbed islet -cell function examined in mouse pancreas tissue slices. J Physiol. 589 (Pt 2):395-408.

 

 Rupnik M. (2009) All together now: exocytose or fail. Islets. 1(1):78-80.

 Paulmann N, Grohmann M, Voigt JP, Bert B, Vowinckel J, Bader M, Skelin M, Jevsek M, Fink H, Rupnik M, Walther DJ. Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation. PLoS Biol. 2009 Oct;7(10):e1000229.

 Sedej S, Gurung IS, Binz T, Rupnik M (2009) Phosphatidylinositol-4,5-bisphosphate-dependent facilitation of the ATP-dependent secretory activity in mouse pituitary cells. Ann N Y Acad Sci. 1152:165-73.

 Rozzo A, Meneghel-Rozzo T, Delakorda SL, Yang SB, Rupnik M (2009) Exocytosis of insulin: in vivo maturation of mouse endocrine pancreas. Ann N Y Acad Sci. 1152:53-62.

 Rupnik M (2009) The physiology of rodent beta-cells in pancreas slices. Acta Physiol (Oxf). 195(1):123-38.

 Cocucci E, Racchetti G, Rupnik M, Meldolesi J (2008) The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4. J Cell Sci.121(Pt 18):2983-91.

 Rose T, Efendic S, Rupnik M (2007) Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats. J Gen Physiol. 129(6):493-508.

 Speier S, Gjinovci A, Charollais A, Meda P, Rupnik M (2007) Cx36-Mediated Coupling Reduces beta-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics. Diabetes. 56(4):1078-86.

 Dudanova I, Sedej S, Ahmad M, Masius H, Sargsyan V, Zhang W, Riedel D, Angenstein F, Schild D, Rupnik M, Missler M (2006) Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules. J Neurosci. 26(41):10599-613.

 Rupnik M, Kreft M, Nothias F, Grilc S, Bobanovic LK, Johannes L, Kiauta T, Vernier P, Darchen F, Zorec R (2006) Distinct role of Rab3A and Rab3B in secretory activity of rat melanotrophs. Am J Physiol Cell Physiol. 292(1):C98-105.

 Kreft M, Blaganje M, Grilc S, Rupnik M, Zorec R. Glutamate stimulation increases hormone release in rat melanotrophs. Neurosci Lett. 404(3):299-302.

 Yang S-B, Major F, Tietze LT, Rupnik M (2005) Block of delayed-rectifier potassium channels by reduced-haloperidol and related compounds in mouse cortical neurons. (2005) J Pharmacol Exp Ther. 315(1):352-362.

 Sedej S, Rose T, Rupnik M (2005) cAMP increases Ca2+-dependent exocytosis through both PKA and Epac2 in mouse melanotrophs from pituitary tissue slices. J Physiol. 567(3):799-813.

 Turner J-E, Sedej S, Rupnik M (2005) Cytosolic Cl- ions in the regulation of secretory and endocytotic activity in melanotrophs from mouse pituitary tissue slices. J Physiol. 566(2):443-453.

 Speier S, Yang S-B, Sroka K, Rose T, Rupnik M. (2005) KATP channels in beta-cells in pancreatic slices are directly modulated by millimolar ATP. Mol Cell Endocrinol. 230(1-2):51-8.

 Rupnik M, Pabst S, Rupnik M, von Eichel-Streiber C, Urlaub H, Soling HD. (2005) Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells. Microbiology. 151(Pt 1):199-208.

 Sedej, S., Rupnik, M., Zorec, R. (2005) Endocytosis requires Rab5 protein in rat melanotrophs (2005) Ann NY Acad Sci 1948:272-280.

 Blyszczuk P, Asbrand C, Rozzo A, Kania G, St-Onge L, Rupnik M, Wobus AM. (2005) Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells. Int J Dev Biol. 48(10):1095-104.

 Cocucci E, Racchetti G, Podini P, Rupnik M, Meldolesi J. (2004) Enlargeosome, an Exocytic Vesicle Resistant to Non-Ionic Detergents, Undergoes Endocytosis via a Non-Acidic Route. Mol Biol Cell. 15(12):5356-68.

 Petrovič U, Šribar J, Pariš A, Rupnik M, Limpel-Kržan M, Vardjan N, Gubenšek F, Zorec R, Križaj I (2004) Ammodytoxin, a neurotoxic secretory phospholipase A2, can act in the cytosol of the nerve cell, Biochem Biophys Res Comm, 324:981-985.

 Yang S-B, Proks P, Ashcroft F M, Rupnik M. (2004) Inhibition of ATP-sensitive potassium channels by haloperidol. Br J Pharmacol. 143(8):960-7

 Meneghel-Rozzo, T., Rozzo, A., Poppi, L., Rupnik, M. (2004) In vivo and in vitro  development of mouse pancreatic β-cells in the organotypic slices. Cell Tiss Res, 316:295-303.

 Kreft, M., Stenovec, M., Rupnik, M., et al.. (2004) Properties of Ca2+-dependent exocytosis in cultured astrocytes. Glia, 46 (4): 437-445.

 Sedej, S., Tsujimoto, T., Zorec, R., Rupnik, M. (2004) Voltage-activated Ca2+ channels and their role in the endocrine function of the pituitatry gland in newborn and adult mice. J Physiol., 555.3: 769-782.

 Speier, S, Rupnik, M. (2003) A novel approach to in situ characterization of pancreatic b-cells. Pflugers Arch-Eur J Physiol 446(5) 553-558.

     

CONTACT INFORMATION:

Prof. Dr. Marjan S. Rupnik
Institute of Physiology
Faculty of Medicine University of Maribor
Slomskov trg 15
2000 Maribor
Slovenia

phone: +386 2 330 5854
fax:   +386 2 330 5853
email: najramkinpur@gmail.com

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